Background: Telemedicine and digital health technologies hold great promise for improving clinical care of heart failure.However, inconsistent and contradictory findings from randomized controlled trials have so far discouraged widespread adoption of digital health in routine clinical practice.We undertook this review study to summarize the study o
Pofut1 point-mutations that disrupt O-fucosyltransferase activity destabilize the protein and abolish Notch1 signaling during mouse somitogenesis.
The segmental pattern of the vertebrate body is established via the periodic formation of somites from the presomitic mesoderm (PSM).This periodical process is controlled by the cyclic and synchronized activation of Notch signaling in the PSM.Protein O-fucosyltransferase1 (Pofut1), which transfers O-fucose to the EGF domains of the Notch1 receptor,
Progress in Developing Inhibitors of SARS-CoV-2 3C-Like Protease
Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).The viral outbreak started in late 2019 and rapidly became a serious Sunscreen health threat to the global population.COVID-19 was declared a pandemic by the World Health Organization in March 2020.Several therapeutic options have been adop